Erik ten Hag names side to take on Cadiz
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Brandon Williams make his first appearance of the season, after recovering from injury, and is set to start at left-back, with Aaron Wan-Bissaka also available again and in the line-up.
Teden Mengi plays alongside Victor Lindelof at the heart of the defence and Martin Dubravka keeps goal, with David De Gea not involved.
Zidane Iqbal and Donny van de Beek are included in midfield, with their positions possibly interchangeable, while captain Scott McTominay can anchor things in the engine room.
There are likely to be a number of substitutions in the second half as Erik takes a close look at his squad.
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